Kotchen J M, McKean H E, Kotchen T A
Am J Epidemiol. 1982 Jun;115(6):861-7. doi: 10.1093/oxfordjournals.aje.a113373.
To determine if gestational hypertension during adolescent pregnancy is associated with subsequently elevated blood pressure, blood pressures were measured in young mothers 3-6 years and again at 6-9 years after their first pregnancy. Follow-up study groups were selected from an original study population of 409 pregnant adolescent women followed at the university of Kentucky Medical Center between 1971 and 1974 in a specially designated Young Mothers' Program. Blood pressures measured during the first and second follow-up surveys were highly correlated. Compared to matched control subjects who remained normotensive throughout pregnancy (n = 54), women with a history of hypertension during pregnancy (n = 70) were heavier, maintained higher blood pressure, and had a greater incidence of hypertension in subsequent pregnancies. At the second follow-up survey, systolic blood pressure and body weight of male children born to women who experienced gestational hypertension were greater than respective values in males born to women with normotensive pregnancies. Blood pressures of female children of the two groups of young mothers did not differ. Overall, blood pressures and body weights of young mothers correlated with blood pressures and body weights of both their children and their own mothers. The results suggest that gestational hypertension may unmask a tendency for hypertension.
为了确定青少年孕期的妊娠高血压是否与随后血压升高有关，研究人员对年轻母亲在首次怀孕后3至6岁以及6至9岁时测量了血压。随访研究组是从1971年至1974年在肯塔基大学医学中心一个专门指定的年轻母亲项目中随访的409名怀孕青少年女性的原始研究人群中选取的。第一次和第二次随访调查期间测量的血压高度相关。与整个孕期血压正常的匹配对照对象（n = 54）相比，有孕期高血压病史的女性（n = 70）体重更重，血压维持在较高水平，且后续妊娠中高血压发病率更高。在第二次随访调查中，患有妊娠高血压的女性所生男性儿童的收缩压和体重高于血压正常妊娠女性所生男性儿童的相应值。两组年轻母亲所生女性儿童的血压没有差异。总体而言，年轻母亲的血压和体重与她们孩子以及她们自己母亲的血压和体重相关。结果表明，妊娠高血压可能揭示了高血压倾向。
