Farrell D A, Medsger T A
Am J Med. 1982 Jul;73(1):57-62. doi: 10.1016/0002-9343(82)90926-3.
Trigeminal neuropathy was identified in 16 (4 percent) of 442 consecutive patients with progressive systemic sclerosis (PSS) who were first evaluated during the period between 1972 and 1980. These cases, together with 25 others that are adequately documented in the literature, were reviewed and compared with the 426 cases of PSS (96 percent) without trigeminal neuropathy. Trigeminal neuropathy occurred most frequently in young women with PSS in overlap with other disorders, particularly the mixed connective tissue disease syndrome with clinical evidence of myositis. Serum antibodies to ribonucleoprotein were identified in nine (45 percent) of 20 PSS patients with trigeminal neuropathy as compared to 25 (8 percent) of 329 PSS patients without trigeminal neuropathy. Leukopenia, hypothyroidism, and Sjögren's syndrome were also found to be associated with trigeminal neuropathy.
在1972年至1980年期间首次接受评估的442例进行性系统性硬化症（PSS）连续患者中，有16例（4%）被诊断为三叉神经病变。对这些病例以及文献中充分记载的其他25例病例进行了回顾，并与426例无三叉神经病变的PSS病例（96%）进行了比较。三叉神经病变最常发生于患有PSS且合并其他疾病的年轻女性，尤其是伴有肌炎临床证据的混合性结缔组织病综合征。20例患有三叉神经病变的PSS患者中有9例（45%）检测到抗核糖核蛋白血清抗体，而329例无三叉神经病变的PSS患者中有25例（8%）检测到该抗体。还发现白细胞减少、甲状腺功能减退和干燥综合征与三叉神经病变有关。
