Khodadoust A A, Attarzadeh A
Am J Ophthalmol. 1982 Jun;93(6):718-22. doi: 10.1016/0002-9394(82)90466-4.
Two men (58 and 19 years of age) had an unusual recurrent, bilaterally symmetric disease process involving the cornea. It is characterized by stromal edema progressing centrally from the periphery in otherwise normal eyes. The corneal edema in each instance was closely associated with slowly moving linear keratic precipitates accompanied by the destruction of the endothelium, with minimal anterior chamber reaction. There was no history of herpetic keratitis or trauma, and serologic tests for syphilis were negative in both cases. A similar pattern of linear endothelial destruction has been reported heretofore only in association with corneal allograft rejection. This clinical pattern, the cytologic findings for the aqueous humor (macrophages and lymphocytes), and the rapid response to corticosteroid therapy suggested that an autoimmune process was the underlying cause of this disease.
两名男性（年龄分别为58岁和19岁）患有一种累及角膜的不寻常的复发性双侧对称性疾病过程。其特征是在其他方面正常的眼睛中，角膜基质水肿从周边向中央进展。在每个病例中，角膜水肿都与缓慢移动的线性角膜后沉着物密切相关，并伴有内皮细胞破坏，前房反应轻微。没有疱疹性角膜炎或外伤史，且两例梅毒血清学检测均为阴性。迄今为止，仅在角膜移植排斥反应中报道过类似的线性内皮细胞破坏模式。这种临床模式、房水的细胞学检查结果（巨噬细胞和淋巴细胞）以及对皮质类固醇治疗的快速反应提示自身免疫过程是该疾病的潜在病因。
