镰状细胞病中的多胺与珠蛋白结合
Polyamines and globin binding in sickle cell disease.
作者信息
Natta C L, Motyczka A A, Kremzner L T
出版信息
Am J Pediatr Hematol Oncol. 1982 Spring;4(1):73-6.
PMID:7091579
Abstract
Erythrocytes obtained from patients with sickle cell anemia contain five to ten times more spermine than controls. The preferential binding of beta s globin to red cell stroma may be mediated by spermine and may account in part for the membrane abnormalities found in sickle cell disorders.
摘要
从镰状细胞贫血患者体内获取的红细胞所含的精胺比对照组多五到十倍。βs珠蛋白与红细胞基质的优先结合可能由精胺介导，并且可能部分解释了镰状细胞疾病中发现的膜异常。
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