Malone J B, Smith P H, Loyacano A F, Hembry F G, Brock L T
Am J Vet Res. 1982 May;43(5):879-81.
In calves given various doses of albendazole as a 4.55% (w/v) drench suspension, removal efficacies against mature Fasciola hepatica were 77.5% with the dose of 7.5 mg/kg; 92.3%, with 10 mg/kg; and 85.9%, with 15 mg/kg. Against immature F hepatica, drug efficacies with these doses were 32.7%, 20.0%, and 36.7%, respectively. Reductions in length and width measurements of mature and immature flukes recovered from the bile ducts correlated with the larger doses reflected a greater efficacy against mature flukes or a possible inhibiting effect of the drug on fluke size or growth. Numbers of eggs recovered in bile at necropsy were reduced by 87.8% with the dose of 7.5 mg/kg; 91.8%, with 10 mg/kg; and 95.6%, with 15 mg/kg.
给犊牛灌服不同剂量的4.55%（w/v）阿苯达唑混悬液后，对成熟肝片吸虫的驱除率分别为：7.5mg/kg剂量组为77.5%；10mg/kg剂量组为92.3%；15mg/kg剂量组为85.9%。对未成熟肝片吸虫，这些剂量的药物疗效分别为32.7%、20.0%和36.7%。从胆管中回收的成熟和未成熟吸虫的长度和宽度测量值的减小与较大剂量相关，这反映出对成熟吸虫的疗效更高，或者该药物对吸虫大小或生长可能具有抑制作用。尸检时胆汁中回收的虫卵数量，7.5mg/kg剂量组减少了87.8%；10mg/kg剂量组减少了91.8%；15mg/kg剂量组减少了95.6%。
