Ahmed A R, Sofen H
Arch Dermatol. 1982 Jun;118(6):423-4.
Two families with pemphigus vulgaris were observed. In one family, cutaneous and mucous membrane pemphigus developed in a mother and daughter within a nine-year interval. In the other family, pemphigus developed in a brother and sister simultaneously. The diagnosis was confirmed immunopathologically in all four patients. Clinical disease did not develop in the other family members. Studies in families with pemphigus can provide further understanding of genetic and environmental factors involved in the pathogenesis of pemphigus.
观察到两个寻常型天疱疮家族。在一个家族中，一位母亲和女儿在九年时间间隔内先后出现皮肤和黏膜天疱疮。在另一个家族中，一对兄妹同时患上天疱疮。所有四名患者均通过免疫病理学确诊。其他家庭成员未出现临床疾病。对天疱疮家族的研究有助于进一步了解天疱疮发病机制中涉及的遗传和环境因素。
