Wain W H, Drury P J, Ross D N
Ann Thorac Surg. 1982 Jun;33(6):562-9. doi: 10.1016/s0003-4975(10)60813-2.
Three hundred thirteen patients underwent aortic valve replacement with 319 Starr-Edwards caged-ball prostheses and have been followed for 1 to 14 years. Hospital mortality (24.8%) and first-year mortality (4.8%) suggest that this is a high-risk group. Overall postoperative patients survival was 37.1%, with 18.8% free from any event, at 14 years. Thromboembolism was the most significant single event (a probability of 18.7% at 14 years), and the Series 2300/2320 valves were associated with a probability of hemolysis of nearly 80% over 13 years. Patients who underwent valve replacement before 1973 had a significantly greater probability of late death (31.1%) and of complications (47.1%) during the first 5 years. Those patients undergoing replacement after 1973 had a significantly greater probability of thromboembolic episodes (15.4%). Starr-Edwards cage-ball prosthesis provide an acceptable valve replacement for high-risk patients. However, the overall complication rate of 81.2% over 14 years, compared with 78% for homograft valves for the same period, does not support the adoption of this prosthesis as the valve of first choice at this hospital.
313例患者接受了主动脉瓣置换术，使用了319个斯塔尔-爱德华兹笼球式人工瓣膜，并随访了1至14年。医院死亡率（24.8%）和第一年死亡率（4.8%）表明这是一个高危群体。术后患者总体生存率为37.1%，14年时18.8%无任何事件发生。血栓栓塞是最显著的单一事件（14年时发生率为18.7%），2300/2320系列瓣膜在13年期间溶血发生率近80%。1973年前接受瓣膜置换的患者在最初5年发生晚期死亡（31.1%）和并发症（47.1%）的概率显著更高。1973年后接受置换的患者发生血栓栓塞事件的概率显著更高（15.4%）。斯塔尔-爱德华兹笼球式人工瓣膜为高危患者提供了可接受的瓣膜置换选择。然而，14年期间总体并发症发生率为81.2%，同期同种异体瓣膜为78%，这表明在该医院该人工瓣膜不应作为首选瓣膜。
