Peters M A, Hudson P M
Arch Int Pharmacodyn Ther. 1982 Mar;256(1):134-44.
Sperm positive (day zero gestation) Fischer 344 rats were exposed to air or to 1500 ppm enflurane by inhalation for 6 hr a day for 21 consecutive days. Enflurane exposed females and their controls were allowed to deliver and raise their offspring. Offspring were studied for evidence of abnormal development as two day, 4, 8, 14 and 80 to 90 week old animals. Thorough gross and histopathological examinations, organ/body weight ratios, clinical chemical and hematological, and overall growth and behavioral examinations were carried out in various aged animals. Sex differences were seen in many parameters as expected, but statistically significant treatment related effects were observed only in the food maze learning behavior and in the pentobarbital sleeping time in the puberty aged male offspring. From our data we can conclude that offspring of pregnant female rats exposed to enflurane at 1500 ppm throughout gestation show minimal, if any, significant clinical or behavioral pathological effects.
精子呈阳性（妊娠第零天）的Fischer 344大鼠每天吸入空气或1500 ppm安氟醚，连续21天，每天6小时。让暴露于安氟醚的雌性大鼠及其对照分娩并抚养后代。对后代作为2日龄、4周龄、8周龄、14周龄以及80至90周龄的动物进行异常发育证据的研究。对不同年龄的动物进行了全面的大体和组织病理学检查、器官/体重比、临床化学和血液学检查，以及整体生长和行为检查。正如预期的那样，在许多参数中发现了性别差异，但仅在青春期雄性后代的食物迷宫学习行为和戊巴比妥睡眠时间方面观察到与治疗相关的统计学显著影响。根据我们的数据可以得出结论，在整个妊娠期暴露于1500 ppm安氟醚的怀孕雌性大鼠的后代，即使有显著的临床或行为病理学影响，也是微乎其微的。
