Probucol: effects on the metabolism of low density and high density lipoproteins in moderate hypercholesterolaemia.

Seven patients with primary hypercholesterolaemia (baseline levels 7.5 to 13.1 mmol/l), and with no evidence of xanthomas, were treated with probucol 1 g daily. Plasma LDL-cholesterol decreased by 20% due to reduced LDL apo B synthetic rate. HDL-cholesterol also decreased; this fall was confined to the HDL3 subclass, while HDL2-cholesterol was unchanged.