多巴胺对人胃平滑肌的作用。

The effect of dopamine on human gastric smooth muscle.

作者信息

Thompson B K, de Carle D J

出版信息

Aust J Exp Biol Med Sci. 1982 Feb;60(Pt 1):123-7. doi: 10.1038/icb.1982.12.

DOI:10.1038/icb.1982.12

Abstract

Dopamine had inhibitory effects on contractions of human gastric smooth muscle strips. Inhibition of spontaneous contractions occurred at high concentrations only, the mean maximum inhibition being 17% at a concentration of 4.7 X 10(-4) M. It was unaffected by haloperidol (10(-5) M) or tetrodotoxin (10(-6) M) but was abolished by a combination of phenoxybenzamine (10(-5) M) and propranolol (10(-5) M). Isoprenaline caused a dose-dependent inhibition of spontaneous contractions with mean maximal inhibition at a concentration of 4.6 X 10(-6) M. These results suggest that there are no specific dopamine receptors in human gastric smooth muscle and that dopamine-induced inhibitory effects are due to stimulation of adrenergic receptors.

摘要

多巴胺对人胃平滑肌条的收缩有抑制作用。仅在高浓度时才会抑制自发性收缩，在浓度为4.7×10⁻⁴M时，平均最大抑制率为17%。它不受氟哌啶醇（10⁻⁵M）或河豚毒素（10⁻⁶M）的影响，但苯氧苄胺（10⁻⁵M）和普萘洛尔（10⁻⁵M）联合使用可消除这种抑制作用。异丙肾上腺素引起自发性收缩的剂量依赖性抑制，在浓度为4.6×10⁻⁶M时平均最大抑制率出现。这些结果表明，人胃平滑肌中不存在特异性多巴胺受体，多巴胺诱导的抑制作用是由于肾上腺素能受体的刺激。