Danzmann R G, Down N E
Biochem Genet. 1982 Feb;20(1-2):1-15. doi: 10.1007/BF00484931.
Interspecific genetic differences in malate dehydrogenase (MDH), lactate dehydrogenase (LDH), superoxide dismutase (SOD), and esterase (EST) isozymes in carp (Cyprinus carpio) and goldfish (Carassius auratus) were used to examine the allelic expressions in the hybrid between these species. A unique liver SOD and muscle LDH phenotype unambiguously identifies all presumed hybrid individuals. There was no evidence of F2 or backcross phenotypes in hybrid individuals. Liver MDH and EST phenotypes in hybrids show a preferential expression of goldfish isozymes. Variation in the levels of carp liver MDH isozymes may result from the polymorphism of a regulatory mutation effecting isozyme expression, leading to gene silencing after duplication.
利用鲤鱼（Cyprinus carpio）和金鱼（Carassius auratus）之间苹果酸脱氢酶（MDH）、乳酸脱氢酶（LDH）、超氧化物歧化酶（SOD）和酯酶（EST）同工酶的种间遗传差异，来检测这些物种之间杂交后代的等位基因表达。一种独特的肝脏SOD和肌肉LDH表型能够明确识别所有假定的杂交个体。在杂交个体中没有F2或回交表型的证据。杂交个体的肝脏MDH和EST表型显示金鱼同工酶有优先表达。鲤鱼肝脏MDH同工酶水平的变化可能是由于影响同工酶表达的调控突变的多态性导致的，这种突变会在基因复制后导致基因沉默。
