大鼠泪腺中钙离子和钙调蛋白依赖性蛋白磷酸化作用
Ca2+- and calmodulin-dependent protein phosphorylation in rat lacrimal gland.
作者信息
Dartt D A, Guerina V J, Donowitz M, Taylor L, Sharp G W
出版信息
Biochem J. 1982 Mar 15;202(3):799-802. doi: 10.1042/bj2020799.
Abstract
Ca2+, in homogenized lacrimal glands, enhanced phosphorylation of several peptides. Phosphorylation of two of these peptides was further stimulated by addition of the Ca2+-binding protein calmodulin and decreased by trifluoperazine, an inhibitor of Ca2+--calmodulin-dependent activity. Thus, Ca2+--calmodulin-dependent protein kinases and their substrates are present in lacrimal gland and could have an important role in lacrimal-gland function.
摘要
在匀浆的泪腺中，钙离子增强了几种肽的磷酸化。添加钙离子结合蛋白钙调蛋白可进一步刺激其中两种肽的磷酸化，而三氟拉嗪（一种钙离子-钙调蛋白依赖性活性抑制剂）则可使其磷酸化减少。因此，钙离子-钙调蛋白依赖性蛋白激酶及其底物存在于泪腺中，可能在泪腺功能中发挥重要作用。
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