Ruifrok P G
Biochem Pharmacol. 1982 Apr 1;31(7):1431-5. doi: 10.1016/0006-2952(82)90039-9.
In order to elucidate the mechanism by which quaternary ammonium compounds are transported across the rat hepatocyte plasma membrane, the transport of five quaternary ammonium compounds through rat hepatocyte plasma membrane vesicles was investigated. Transport is only observed when the organic cations possess a high lipophilicity. Uptake appeared to be a passive process and was not stimulated by a transmembrane electrical potential difference nor by the presence of an excess of anions like I-. Taurocholate decreased the uptake. However in the presence of a catalytic amount of tetraphenylborate a transmembrane electrical potential difference (inside negative) stimulated the uptake.
为了阐明季铵化合物跨大鼠肝细胞质膜转运的机制，研究了五种季铵化合物通过大鼠肝细胞质膜囊泡的转运。仅当有机阳离子具有高亲脂性时才观察到转运。摄取似乎是一个被动过程，不受跨膜电势差或过量阴离子（如I-）的存在刺激。牛磺胆酸盐降低了摄取。然而，在催化量的四苯硼酸盐存在下，跨膜电势差（内部为负）刺激了摄取。
