Espinoza L R, Vasey F B, Espinoza C G, Bocanegra T S, Germain B F
Arthritis Rheum. 1982 Jun;25(6):677-84. doi: 10.1002/art.1780250611.
Light and electron microscopic studies were performed on the synovial membranes from the large joints of 12 patients with psoriatic arthritis. The most significant histopathologic findings were vascular changes that were characterized by endothelial cell swelling accompanied by inflammatory cell infiltration and marked thickening of the vessel wall. Fibrosis of the subsynoviocyte tissue was also prominent, especially in patients with chronic disease. Villi were not prominent, and the lining layer was not thickened. Both type A and B cells were seen; none had significant abnormalities. No electrondense deposits were observed. These findings lend further support to the theory that microvascular changes play a significant role in the pathogenesis of psoriasis and its related arthritis.
对12例银屑病关节炎患者大关节的滑膜进行了光镜和电镜研究。最显著的组织病理学发现是血管变化，其特征为内皮细胞肿胀，伴有炎症细胞浸润和血管壁明显增厚。滑膜下组织纤维化也很突出，尤其是在慢性病患者中。绒毛不突出，衬里层未增厚。可见A、B两型细胞；均无明显异常。未观察到电子致密沉积物。这些发现进一步支持了微血管变化在银屑病及其相关关节炎发病机制中起重要作用的理论。
