Wegman D H, Peters J M, Boundy M G, Smith T J
Br J Ind Med. 1982 Aug;39(3):233-8. doi: 10.1136/oem.39.3.233.
Miners and millers of talc ore, free from asbestos and silica, were examined for respiratory effects. A study of 116 subjects included the modified British Medical Research Council respiratory symptom questionnaire, simple spirometry, chest radiography, and limited examination of the chest. A one-year follow-up evaluation was performed on 103 subjects. Of the 12 subjects whose chest radiographs showed small round or irregular opacities (perfusion 1/0 or greater), five had never smoked cigarettes. Pulmonary function values at the time of the initial study were less than predicted and the rates of loss of FEV1 and FVC greater than expected. These differences were in part attributed to cigarette smoking but were greater than predicted from that source alone. There was evidence of an exposure effect after adjusting for cigarette smoking and we conclude that these workers have been affected by their exposures. No clear interaction between smoking and exposure could be identified. Populations such as this will need to be studied for longer periods to determine what current dust levels are safe.
对不含石棉和二氧化硅的滑石矿石矿工和研磨工人进行了呼吸影响方面的检查。一项针对116名受试者的研究包括改良的英国医学研究委员会呼吸症状问卷、简易肺量计检查、胸部X光检查以及有限的胸部检查。对103名受试者进行了为期一年的随访评估。在胸部X光片显示有小圆形或不规则阴影（1/0级或更高）的12名受试者中，有5人从不吸烟。初始研究时的肺功能值低于预测值，FEV1和FVC的下降速率高于预期。这些差异部分归因于吸烟，但仅从这一因素来看又大于预期。在对吸烟进行校正后，有暴露效应的证据，我们得出结论，这些工人受到了他们所接触物质的影响。未发现吸烟与暴露之间有明显的相互作用。需要对这类人群进行更长时间的研究，以确定当前何种粉尘水平是安全的。
