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步进发生器的双室模型:对一个阶段设定器和一个节律发生器作用的分析。

A two compartment model of the stepping generator: analysis of the roles of a stage-setter and a rhythm generator.

作者信息

Kawahara K, Mori S

出版信息

Biol Cybern. 1982;43(3):225-30. doi: 10.1007/BF00319981.

DOI:10.1007/BF00319981
PMID:7093363
Abstract

Recent studies on locomotion of the mesencephalic cat demonstrated that activation of the spinal stepping generator and the postural control system are dependent phenomena (Mori et al., 1978, 1980). This has motivated the construction of a new model of the stepping generator to account for interactions with the postural control system. The present model consists of two main compartments, the rhythm generator and the stage-setter. The rhythm generator generates rhythmic bursting discharges of extensor and flexor alpha motoneurons. The function of the stage-setter is to set and reset the excitability of extensor alpha motoneuron to a number of desired levels. This study analyzes interactions in this model between rhythm generating and postural control system. By adding a concept of "stage-setting" to the rhythm generator model, we succeed in simulating a variety of locomotor patterns observed in the mesencephalic cat, including "stepping automatism" (Mori et al., 1979).

摘要

最近对中脑猫运动的研究表明,脊髓步进发生器的激活和姿势控制系统是相关现象(森等人,1978年,1980年)。这促使构建一种新的步进发生器模型,以解释与姿势控制系统的相互作用。当前模型由两个主要部分组成,即节律发生器和阶段设定器。节律发生器产生伸肌和屈肌α运动神经元的节律性爆发放电。阶段设定器的功能是将伸肌α运动神经元的兴奋性设定并重置为多个期望水平。本研究分析了该模型中节律生成与姿势控制系统之间的相互作用。通过在节律发生器模型中添加“阶段设定”的概念,我们成功模拟了中脑猫中观察到的各种运动模式,包括“步进自动症”(森等人,1979年)。

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