Efuni S N, Shimkevich L L, Tepliakov V G, Derevianko T P
Biull Eksp Biol Med. 1982 Mar;93(3):110-3.
It has been shown in experiments on dogs that following blood replacement with a plasma substitute up to 0.5-2.5 g/100 ml Hb at an oxygen pressure of 3 at. abs., the morphological changes seen in the cerebral hemispheres, heart, liver, kidneys and lungs assume an adaptation character and are rapidly reversible. Microcirculatory disorders were found to play the leading part in the genesis of cellular changes recorded. The blood analysis data revealed the relationship between the degree of hemodilution and microvascular permeability and overall shifts in energy formation. To reduce the functional tension in the organ tissue systems, it is advisable to exercise the correction of the plasma substitute composition by which the permeability of the histohematic barrier could be stabilized. The hemodilution technique may be applied under hyperbaric oxygenation both in surgery and other fields of medicine with on object of replacing donor's blood by hemodynamic plasma substitutes.
在对狗的实验中发现，在3个绝对大气压的氧压下，用血浆代用品进行血液置换，使血红蛋白达到0.5 - 2.5克/100毫升时，大脑半球、心脏、肝脏、肾脏和肺中出现的形态学变化具有适应性特征，且可迅速逆转。发现微循环障碍在记录到的细胞变化发生过程中起主导作用。血液分析数据揭示了血液稀释程度与微血管通透性以及能量生成总体变化之间的关系。为降低器官组织系统中的功能张力，建议通过调整血浆代用品成分来稳定组织血液屏障的通透性。血液稀释技术可在高压氧治疗下应用于外科手术及其他医学领域，目的是以血液动力学血浆代用品替代供血。
