Chichkanov G G, Bogolepov A K, Tsorin I B, Matsievskiĭ D D
Biull Eksp Biol Med. 1982 Mar;93(3):44-7.
It was shown in experiments on cats anesthesized with nembutal that sodium hydroxybutyrate given in doses of 100 and 200 mg/kg increases the coronary blood flow in the intact myocardium. At the same time oxygen consumption by the heart rises to a far less degree. The drug provokes negligible hypertension, raises the systolic and cardiac outputs, and enhances myocardial contractility. It was discovered in experiments on dogs with the ischemized heart that sodium hydroxybutyrate in a dose of 200 mg/kg increases the blood supply both to the intact and ischemized myocardium areas. Changes in myocardial ischemia duration and in the hemodynamics produced by sodium hydroxybutyrate are similar to those caused by the drug in experiments with the intact heart.
在用戊巴比妥麻醉的猫身上进行的实验表明，剂量为100和200毫克/千克的羟丁酸钠可增加完整心肌的冠状动脉血流量。与此同时，心脏的耗氧量上升幅度要小得多。该药物引起的高血压可忽略不计，可提高收缩压和心输出量，并增强心肌收缩力。在用缺血心脏的狗身上进行的实验中发现，剂量为200毫克/千克的羟丁酸钠可增加完整心肌区域和缺血心肌区域的血液供应。羟丁酸钠引起的心肌缺血持续时间和血流动力学变化与在完整心脏实验中该药物引起的变化相似。
