L-脯氨酸及相关化合物：结构、致遗忘效力与抗扩散性抑郁效力的相关性

L-Proline and related compounds: correlation of structure, amnesic potency and anti-spreading depression potency.

作者信息

Cherkin A, Van Harreveld A

出版信息

Brain Res. 1978 Nov 10;156(2):265-73. doi: 10.1016/0006-8993(78)90508-5.

Abstract

The effects of L-proline, D-proline, and L-azetidine-2-carboxylic acid (L-A.2.C., the lower homolog of L-proline) have been compared in two systems. L-Proline is more potent than either analog in causing amnesia of one-trial avoidance conditioning of the 2-day-old chick and in preventing mechanically induced spreading depression in the retina isolated from 2-3-week-old chicks. The results suggest that the L-configuration and the proper molecular size are essential for the effects of L-proline upon memory and upon spreading depression. This level of specificity is greater than that involved in protein synthesis because L-A.2.C. is incorporated into protein in place of L-proline, in several protein-synthesizing systems.

摘要

在两个系统中比较了L-脯氨酸、D-脯氨酸和L-氮杂环丁烷-2-羧酸（L-A.2.C.，L-脯氨酸的低级同系物）的作用。在导致2日龄雏鸡一次性回避条件反射失忆以及预防从2至3周龄雏鸡分离的视网膜中机械诱导的扩散性抑制方面，L-脯氨酸比任何一种类似物都更有效。结果表明，L-构型和合适的分子大小对于L-脯氨酸对记忆和扩散性抑制的作用至关重要。这种特异性水平高于蛋白质合成中所涉及的特异性，因为在几个蛋白质合成系统中，L-A.2.C.会取代L-脯氨酸掺入蛋白质中。