苯海索对犬爪垫血管舒张神经刺激反应的延长作用。
Benztropine-induced prolongation of responses to vasodilator nerve stimulation in the canine paw pad.
作者信息
Bell C
出版信息
Br J Pharmacol. 1982 Jun;76(2):231-3. doi: 10.1111/j.1476-5381.1982.tb09211.x.
Abstract
After blockade of noradrenergic transmission with guanethidine in anaesthetized dogs, stimulation of the peripheral end of the cut tibial nerve (1 Hz, 10 pulses) produces a vasodilator response which is localized to the circulation of the paw pads. The time course of the response is considerably prolonged after systemic administration of the dopamine-uptake blocking drug, benztropine (1 mg/kg). This effect is not due to inhibition of Uptake 1, as benztropine, unlike desmethylimipramine, does not prolong responses to noradrenergic vasoconstrictor nerve stimulation. The results support previous evidence suggesting that the dilator response to tibial nerve stimulation involves neural release of dopamine.
摘要
在对麻醉犬用胍乙啶阻断去甲肾上腺素能传递后，刺激切断的胫神经外周端（1赫兹，10个脉冲）会产生一种血管舒张反应，该反应局限于爪垫的循环系统。在全身给予多巴胺摄取阻断药物苯海索（1毫克/千克）后，该反应的时间进程显著延长。这种效应并非由于对摄取1的抑制，因为与去甲丙咪嗪不同，苯海索不会延长对去甲肾上腺素能血管收缩神经刺激的反应。这些结果支持了先前的证据，表明对胫神经刺激的舒张反应涉及多巴胺的神经释放。
相似文献
1
Benztropine-induced prolongation of responses to vasodilator nerve stimulation in the canine paw pad.苯海索对犬爪垫血管舒张神经刺激反应的延长作用。
Br J Pharmacol. 1982 Jun;76(2):231-3. doi: 10.1111/j.1476-5381.1982.tb09211.x.
2
Evidence for dopaminergic vasodilator innervation of the canine paw pad.犬爪垫多巴胺能血管舒张神经支配的证据。
Br J Pharmacol. 1979 Nov;67(3):337-43. doi: 10.1111/j.1476-5381.1979.tb08685.x.
3
Influence of histamine H1- and H2-receptor blockers on sympathetic vasodilator and vasoconstrictor responses in canine paw.组胺H1和H2受体阻滞剂对犬爪部交感神经舒血管和缩血管反应的影响。
Br J Pharmacol. 1975 Jan;53(1):51-8. doi: 10.1111/j.1476-5381.1975.tb07329.x.
4
Effects on renal sympathetic axons in dog of acute 6-hydroxydopamine treatment in combination with selective neuronal uptake inhibitors.急性6-羟基多巴胺治疗联合选择性神经元摄取抑制剂对犬肾交感神经轴突的影响。
Br J Pharmacol. 1990 Apr;99(4):655-60. doi: 10.1111/j.1476-5381.1990.tb12985.x.
5
Differentiation of vasodilator and sudomotor responses in the cat paw pad to preganglionic sympathetic stimulation.猫爪垫对节前交感神经刺激的血管舒张和发汗反应的分化
J Physiol. 1985 Jul;364:93-104. doi: 10.1113/jphysiol.1985.sp015732.
6
Differential effects of benztropine and desipramine on the high affinity uptake of paratyramine in slices of the caudate nucleus and hypothalamus.
Neurochem Res. 1980 Mar;5(3):297-300. doi: 10.1007/BF00964617.
7
Influence of basal perfusion pressure on vasoconstrictor and vasodilator responses induced sympathetically and reflexly in pump-perfused rat hindquarters.基础灌注压对泵灌注大鼠后肢交感神经和反射性诱导的血管收缩及舒张反应的影响。
Arch Int Pharmacodyn Ther. 1986 Sep;283(1):105-23.
8
Proceedings: Vasodilatation in the canine paw pad evoked by brain stimulation or local cooling.
J Physiol. 1974 Sep;241(2):112P-113P.
9
Noncholinergic vasodilator innervation in the feet of ducks.
Am J Physiol. 1979 Aug;237(2):H112-7. doi: 10.1152/ajpheart.1979.237.2.H112.
10
Pharmacological investigations of the vasodilator nerves supplying the duck's foot.对供应鸭足的血管舒张神经的药理学研究。
Br J Pharmacol. 1984 Aug;82(4):801-8. doi: 10.1111/j.1476-5381.1984.tb16476.x.
引用本文的文献
1
Effects of 6-hydroxydopamine on dopamine and noradrenaline content in dog blood vessels and heart. Evidence for a noradrenaline-independent dopamine pool.6-羟基多巴胺对犬血管和心脏中多巴胺及去甲肾上腺素含量的影响。关于不依赖去甲肾上腺素的多巴胺池的证据。
Naunyn Schmiedebergs Arch Pharmacol. 1985 May;329(3):253-7. doi: 10.1007/BF00501876.
2
Evidence for a non-precursor dopamine pool in noradrenergic neurones of the dog mesenteric artery.犬肠系膜动脉去甲肾上腺素能神经元中存在非前体多巴胺池的证据。
Naunyn Schmiedebergs Arch Pharmacol. 1986 Jul;333(3):219-23. doi: 10.1007/BF00512932.
3
Dopamine released from nerve terminals activates prejunctional dopamine receptors in dog mesenteric arterial vessels.从神经末梢释放的多巴胺激活了犬肠系膜动脉血管中的突触前多巴胺受体。
Br J Pharmacol. 1987 Jul;91(3):591-9. doi: 10.1111/j.1476-5381.1987.tb11252.x.
本文引用的文献
1
2
Proceedings: Vasodilatation in the canine paw pad evoked by brain stimulation or local cooling.
J Physiol. 1974 Sep;241(2):112P-113P.
3
Involvement of uptake2 in the termination of activity of neurogenic noradrenaline in the rat isolated atrium.摄取2在大鼠离体心房中神经源性去甲肾上腺素活性终止过程中的作用。
J Physiol. 1976 Jan;254(1):203-12. doi: 10.1113/jphysiol.1976.sp011229.
4
Vascular dopamine receptors in the canine hindlimb.犬后肢的血管多巴胺受体
Br J Pharmacol. 1975 Oct;55(2):167-72. doi: 10.1111/j.1476-5381.1975.tb07625.x.
5
Molecular geometry of inhibitors of the uptake of catecholamines and serotonin in synaptosomal preparations of rat brain.大鼠脑突触体制剂中儿茶酚胺和5-羟色胺摄取抑制剂的分子几何学
J Pharmacol Exp Ther. 1976 Dec;199(3):649-61.
6
Involvement of uptake1 and uptake2 in terminating the cardiovascular activity of noradrenaline in normotensive and genetically hypertensive rats.摄取1和摄取2在正常血压和遗传性高血压大鼠中终止去甲肾上腺素心血管活性方面的作用。
J Physiol. 1978 Oct;283:41-51. doi: 10.1113/jphysiol.1978.sp012487.
7
Dopamine-containing axons supplying the arterio-venous anastomoses of the canine paw pad.
J Neurochem. 1978 Nov;31(5):1329-33. doi: 10.1111/j.1471-4159.1978.tb06259.x.
8
Evidence for dopaminergic vasodilator innervation of the canine paw pad.犬爪垫多巴胺能血管舒张神经支配的证据。
Br J Pharmacol. 1979 Nov;67(3):337-43. doi: 10.1111/j.1476-5381.1979.tb08685.x.
Zotero 插件