Cookson J C, Silverstone T, Rees L
Br J Psychiatry. 1982 Mar;140:274-9. doi: 10.1192/bjp.140.3.274.
During two weeks' treatment of 11 manic patients with pimozide there was close correspondence between the timecourse of improvement in clinical ratings and the rise in plasma prolactin between the second and fourteenth day. There were no significant differences in growth hormone levels during the manic episodes compared to recovery. These findings are discussed in relation to the role of dopamine in the release of prolactin and growth hormone, and in the pathogenesis of mania.
在使用匹莫齐特对11名躁狂患者进行为期两周的治疗期间，临床评分改善的时间进程与第二至第十四天血浆催乳素的升高之间存在密切对应关系。与康复期相比，躁狂发作期间生长激素水平没有显著差异。结合多巴胺在催乳素和生长激素释放以及躁狂症发病机制中的作用对这些发现进行了讨论。
