大鼠大脑对降钙素变化的反应。

Response of rat brain to calcitonin alteration.

作者信息

Nakhla A M, Latif A

出版信息

Brain Res. 1982 Apr 29;238(2):489-93. doi: 10.1016/0006-8993(82)90129-9.

Abstract

Endogenous calcitonin was altered in rats by thyroparathyroidectomy, followed by supplementation with thyroxine and calcium. As a result, a reduction in the content of 5-hydroxytryptamine in the brain together with an increase in the concentration of tryptophan in the plasma were observed. The changes were accompanied by a diminution in the activity of both choline acetyltransferase and acetylcholinesterase in the cerebral hemispheres. The results are consistent with those produced by exogenous hormone and suggest that calcitonin probably plays a role in the regulation of 5-hydroxytryptamine levels in the brain.

摘要

通过甲状旁腺切除术改变大鼠体内的内源性降钙素，随后补充甲状腺素和钙。结果发现，大脑中5-羟色胺含量降低，同时血浆中色氨酸浓度升高。这些变化伴随着大脑半球中胆碱乙酰转移酶和乙酰胆碱酯酶活性的降低。这些结果与外源性激素产生的结果一致，表明降钙素可能在调节大脑中5-羟色胺水平方面发挥作用。