Vik A, Yatham L N
Department of Psychiatry, University of British Columbia, Victoria.
J Psychiatry Neurosci. 1998 Mar;23(2):109-17.
Double-blind trials conducted in the early 1980s showed that subcutaneous injections of salmon calcitonin in patients suffering from mania resulted in significant decreases in irritability, euphoria and hyperactivity. Although these results were promising, there were no follow-up studies in this area. A MEDLINE search into the effect of calcitonin on neuronal tissues revealed that calcitonin affects neuronal tissues in a manner similar to that of the currently accepted mood-stabilizing agents--namely by modulating intracellular second messenger signalling mechanisms, stabilizing neuronal membranes and inhibiting neuronal calcium influx. We suggest that these effects of calcitonin on neuronal tissues, combined with earlier clinical research showing its efficacy in treating the acute symptoms of mania, make calcitonin a candidate for further research in the treatment of bipolar disorder.
20世纪80年代初进行的双盲试验表明，对躁狂症患者皮下注射鲑鱼降钙素可显著降低易怒、欣快和多动症状。尽管这些结果很有前景，但该领域没有后续研究。对降钙素对神经组织影响的MEDLINE搜索显示，降钙素对神经组织的影响方式与目前公认的情绪稳定剂类似——即通过调节细胞内第二信使信号传导机制、稳定神经细胞膜和抑制神经钙内流。我们认为，降钙素对神经组织的这些作用，结合早期临床研究显示其在治疗躁狂症急性症状方面的疗效，使降钙素成为双相情感障碍治疗进一步研究的候选药物。
