Mandel E M, Lask D, Gafter U, Weiss S, Kende L, Djaldetti M
Acta Haematol. 1977;58(2):120-8. doi: 10.1159/000207817.
A patient with multiple myeloma (MM) who developed Kaposi sarcoma (KS) is described. The KS appeared 18 months after the diagnosis of MM and 1 month after the treatment was changed from cyclophosphamide to melphalan. The treatment with melphalan was discontinued and the spread of the KS was arrested by irradiation and bleomycin. One month after the melphalan was restarted, the KS advanced. The patient died 28 months after the diagnosis of MM and 10 months after KS had developed. The association of KS and MM is discussed and the previously reported cases are reviewed. A possible connection between the treatment with melphalan and the development of KS is proposed.
本文描述了一名患有多发性骨髓瘤（MM）并发生卡波西肉瘤（KS）的患者。KS在MM诊断后18个月出现，且在治疗从环磷酰胺改为美法仑1个月后出现。美法仑治疗中断，KS的扩散通过放疗和博来霉素得以控制。美法仑重新开始使用1个月后，KS病情进展。该患者在MM诊断后28个月以及KS出现后10个月死亡。文中讨论了KS与MM的关联，并回顾了既往报道的病例。提出了美法仑治疗与KS发生之间可能存在的联系。
