携带皮肤黑色素瘤的小型辛克莱猪的细胞介导免疫反应。
Cell mediated immune response in miniature Sinclair swine bearing cutaneous melanomas.
作者信息
Jones D H, Amoss M S
出版信息
Can J Comp Med. 1982 Apr;46(2):209-11.
Abstract
Miniature Sinclair swine bearing cutaneous melanomas and nonmelanoma bearing littermate controls were tested for lymphocyte blastogenic response in a microculture assay. Lymphocytes were assayed for 3H-thymidine incorporation following stimulation with concanavalin A, phytohemagglutinin or pokeweed mitogen. Treatment with all mitogens revealed a significantly (p less than 0.05) reduced proliferative capacity in melanoma swine as compared to littermate controls. These results lend further support for the use of miniature Sinclair swine as a research model for human melanoma.
摘要
对患有皮肤黑色素瘤的小型辛克莱猪及其未患黑色素瘤的同窝对照仔猪进行了微培养试验，以检测淋巴细胞的增殖反应。在用刀豆球蛋白A、植物血凝素或商陆有丝分裂原刺激后，检测淋巴细胞对3H-胸腺嘧啶核苷的掺入情况。与同窝对照相比，所有有丝分裂原处理均显示黑色素瘤猪的增殖能力显著降低（p<0.05）。这些结果进一步支持了将小型辛克莱猪用作人类黑色素瘤研究模型。
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