Feffer S E, Westring D W, Lee A C, Lin J H
Cancer. 1982 Aug 1;50(3):396-400. doi: 10.1002/1097-0142(19820801)50:3<396::aid-cncr2820500303>3.0.co;2-n.
A 63-year-old man presented with fever, easy bruisability, splenomegaly and pancytopenia. Bone marrow aspiration was unsuccessful, and marrow biopsy revealed crowding by sheets of mononuclear cells; a diagnosis of leukemic reticuloendotheliosis (LRE) was made and the patient underwent splenectomy. There was no hematologic improvement, and the patient continued to have a significant requirement for erythrocytes and platelet transfusions. Within two months of beginning oxymetholone therapy (50 mg orally three times a day) the patient's platelet count had normalized, followed by improved erythrocyte and leukocyte counts. When the drug was discontinued, the peripheral blood counts deteriorated drastically; he again demonstrated hematologic improvement when oxymetholone therapy was reinstated. We feel that by demonstrating a hematologic response to oxymetholone, relapse when it was withdrawn, and another remission upon readministration, that we have provided stronger evidence than previously reported for the efficacy of this drug in LRE.
一名63岁男性患者出现发热、易瘀斑、脾肿大和全血细胞减少。骨髓穿刺未成功，骨髓活检显示有大量单核细胞聚集；诊断为白血病性网状内皮细胞增生症（LRE），患者接受了脾切除术。血液学指标未改善，患者仍需要大量输注红细胞和血小板。开始使用氧甲氢龙治疗（口服50毫克，每日3次）后两个月内，患者血小板计数恢复正常，随后红细胞和白细胞计数也有所改善。停药后，外周血细胞计数急剧恶化；重新使用氧甲氢龙治疗后，血液学指标再次改善。我们认为，通过证明对氧甲氢龙有血液学反应、停药后复发以及再次用药后再次缓解，我们为该药物在LRE中的疗效提供了比以前报道更强有力的证据。
