致癌物对核酸的选择性烷基化可能导致DNA编码错误。一项理论研究。
Selective alkylation of nucleic acids by carcinogens may cause miscoding in DNA. A theoretical study.
作者信息
Klopman G, Ray A
出版信息
Cancer Biochem Biophys. 1982;6(1):31-5.
PMID:7093936
Abstract
The CNDO/II method was used to study the pairing abilities of various alkylated nucleic acids. On the basis of these results, a mechanism for mutation (carcinogenesis) is proposed. Our calculations suggest that O-(6) alkylated guanine and/or O-(4) alkylated thymine could cause miscoding during the replication of DNA.
摘要
采用CNDO/II方法研究了各种烷基化核酸的配对能力。基于这些结果，提出了一种突变（致癌作用）机制。我们的计算表明，O-(6)烷基化鸟嘌呤和/或O-(4)烷基化胸腺嘧啶可能在DNA复制过程中导致错码。
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