Cantrell J E, Brunet R, Lagarde C, Schein P S, Smith F P
Cancer Treat Rep. 1982 Jul;66(7):1563-5.
Eighteen patients with previously untreated advanced colorectal cancer were treated with a sequential methotrexate-5-FU regimen. One of 16 evaluable patients achieved a partial response. The results of this and other clinical and laboratory investigations reported to date suggest that further study of different doses and schedules of sequential methotrexate-5-FU is warranted.