外源性促胰液素输注后人体钙和甲状旁腺激素的变化

Calcium and parathyroid hormone behaviour after exogenous secretin infusion in man.

作者信息

Lo Cascio V, Piubello W, Cominacini L, Vantini I, Galvanini G, Ederle A, Cavallini G, Scuro L A

出版信息

Clin Endocrinol (Oxf). 1982 Apr;16(4):331-6. doi: 10.1111/j.1365-2265.1982.tb00724.x.

DOI:10.1111/j.1365-2265.1982.tb00724.x

Abstract

The response of serum calcium, PTH, CT and gastrin to an infusion of secretin (3 CU/kg/h) over a period of 90 min was studied in ten healthy males and two female patients with hypoparathyroidism. In the healthy males serum calcium, after a transient fall, significantly increased at 45 min after the onset of the infusion (P less than 0.001). Serum iPTH rose significantly within 5 min whereas serum CT and gastrin concentrations did not change. The two hypoparathyroid patients did not show any variations in either serum iPTH or calcium. These findings suggest that infusion of pharmacological doses of secretin into normal subjects modifies serum calcium, and that this change is due to PTH release.

摘要

在10名健康男性和2名甲状旁腺功能减退女性患者中，研究了在90分钟内输注促胰液素（3 CU/kg/h）后血清钙、甲状旁腺激素（PTH）、降钙素（CT）和胃泌素的反应。在健康男性中，血清钙在短暂下降后，在输注开始后45分钟显著升高（P<0.001）。血清免疫反应性甲状旁腺激素（iPTH）在5分钟内显著上升，而血清CT和胃泌素浓度没有变化。两名甲状旁腺功能减退患者的血清iPTH或钙均未显示任何变化。这些发现表明，向正常受试者输注药理剂量的促胰液素会改变血清钙，且这种变化是由于甲状旁腺激素释放所致。