地高辛在持续性非卧床腹膜透析患者中的药代动力学

Pharmacokinetics of digoxin in C.A.P.D.

作者信息

De Paepe M, Belpaire F, Bogaerts Y

出版信息

Clin Exp Dial Apheresis. 1982;6(1):65-73. doi: 10.3109/08860228209050814.

DOI:10.3109/08860228209050814

Abstract

The peritoneal elimination of digoxin during C.A.P.D. was studied in five patients. The plasma half life of digoxin varied from 54 hours to 141 hours. Only 7 to 24 micrograms was eliminated via the peritoneal route during 3 to 4 days C.A.P.D. treatment. The total urinary elimination during the same period ranged from 11 to 57 micrograms. It is concluded that adjustment of dose is not necessary when starting C.A.P.D.

摘要

对5例持续性非卧床腹膜透析（CAPD）患者地高辛的腹膜清除情况进行了研究。地高辛的血浆半衰期为54小时至141小时不等。在3至4天的CAPD治疗期间，经腹膜途径清除的地高辛仅7至24微克。同期经尿液的总清除量为11至57微克。结论是开始CAPD时无需调整剂量。