Barwin B N
Can Med Assoc J. 1978 Oct 7;119(7):757-9.
An updated review of research into contraceptives for men is presented. New concepts of the pharmacologic effects of chemical agents on germinal stem cells and spermatogenic arrest, and the effect of new compounds that act at the post-testicular level but do not affect androgen production are discussed. The latest results of studies on steroidal compounds that inhibit pituitary secretion of gonadotropin and hence result in suppression of spermatogenesis and testosterone secretion are presented. The newer contraceptive pills for men are also evaluated. The major drawback to the development of chemical contraceptives for men is the fear of genetic damage and impotence. New and continued research into this type of contraception is urgently needed.
本文对男性避孕药的研究进行了更新综述。讨论了化学药剂对生殖干细胞和生精停滞的药理作用的新概念，以及作用于睾丸后水平但不影响雄激素产生的新化合物的作用。介绍了抑制垂体促性腺激素分泌从而导致精子发生和睾酮分泌受到抑制的甾体化合物的最新研究结果。还对新型男性避孕药进行了评估。男性化学避孕药开发的主要缺点是担心遗传损伤和阳痿。迫切需要对这类避孕方法进行新的和持续的研究。
