一些典型和非典型抗抑郁药对不同脑区中谷氨酸脱羧酶（GAD）活性的影响。
Effects of some typical and atypical antidepressants on GAD activity in various brain regions.
作者信息
Rampello L, Patti F, Condorelli D F, Reggio A, Prato A, Canonico P L, Nicoletti F
出版信息
Encephale. 1982;8(1):89-94.
PMID:7094872
Abstract
The AA. have investigated the effects of acute or chronic injection of typical and atypical antidepressants on the activity of the GABA--synthesizing enzyme glutamic acid decarboxylase (GAD, EC 4.1.1.15) in discrete brain regions. Very significant changes in GAD activity were only observed with sulpiride and nomifensine, two atypical antidepressants that selectively influence dopaminergic transmission and, in turn, prolactin secretion.
摘要
研究人员调查了急性或慢性注射典型和非典型抗抑郁药对离散脑区中γ-氨基丁酸合成酶谷氨酸脱羧酶（GAD，EC 4.1.1.15）活性的影响。仅在舒必利和诺米芬辛这两种非典型抗抑郁药中观察到GAD活性有非常显著的变化，这两种药物选择性地影响多巴胺能传递，进而影响催乳素分泌。
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