Franzin G, Dina R, Scarpa A, Fratton A
Endoscopy. 1982 Jul;14(4):131-4. doi: 10.1055/s-2007-1021600.
A follow-up study of fourteen out of twenty-seven cases of solitary ulcer syndrome of the rectum was performed at one year's interval from the previous endoscopic and histologic examination. Most of the lesions consistently changed their aspect, resulting in incomplete irregular narrowings, polypoid protrusions or linear ulcers. The symptoms remained unchanged or slightly diminished. A striking difference was found in the histological pattern of the "evolved" ulcer in comparison to the active one, the former showing features of hyperplastic (metaplastic) colonic polyps as well as of the so called "transitional mucosa". It is suggested that chronic ischemia occurring in solitary ulcer of the rectum leads to "transitional mucosa" as an exaggerated regenerative phenomenon, hyperplastic (metaplastic) mucosa representing a later maturative phase. Possibly "transitional" mucosa may undergo dysplastic changes under the influence of environmental factors.
对27例直肠孤立性溃疡综合征中的14例进行了随访研究，自上次内镜和组织学检查起，每隔一年进行一次。大多数病变持续改变其外观，形成不完全性不规则狭窄、息肉样突起或线性溃疡。症状保持不变或略有减轻。与活动性溃疡相比，“进展期”溃疡的组织学模式存在显著差异，前者表现出增生性（化生）结肠息肉以及所谓“移行黏膜”的特征。有人提出，直肠孤立性溃疡中发生的慢性缺血会导致“移行黏膜”作为一种过度的再生现象出现，增生性（化生）黏膜代表后期的成熟阶段。在环境因素的影响下，“移行”黏膜可能会发生发育异常改变。
