肾皮质肾小管离子置换过程中的电压瞬变。

Voltage transients during ionic substitution in renal cortical tubules.

作者信息

Lopes A G, de Mello G B, Malnic G

出版信息

Experientia. 1982 May 15;38(5):588-90. doi: 10.1007/BF02327064.

Abstract

A voltage transient is described which is found during proximal tubular perfusion with impermeant cation or anion salt solutions in the rat. It was shown that the magnitude of transepithelial diffusion potentials depended on luminal hydrostatic pressure, suggesting that the observed transients might be the consequence of the enlargement of ionic pathways by tubular dilatation. Thus, when reporting PD values, care should be taken to define the pressure levels at which measurements were performed.

摘要

描述了一种电压瞬变现象，该现象是在大鼠近端肾小管灌注非渗透性阳离子或阴离子盐溶液过程中发现的。结果表明，跨上皮扩散电位的大小取决于管腔内静水压，这表明观察到的瞬变现象可能是肾小管扩张导致离子通道扩大的结果。因此，在报告PD值时，应注意明确进行测量时的压力水平。