[Results of measuring the blood flow in the gastric mucosa of dogs by the 99mTc-4-methylaminophenazone clearance method].

In anesthetized dogs, a good correlation was found between the [99mTc]-4-methylaminophenazone and aminopyrine clearances measured in the same animal after administration of gastric secretory stimulants vasopressin or glucagon. A similarly good correlation was observed between the [99mTc]-4-methylaminophenazone and [14C]-aminopyrine clearance during histamine administration. The clearance values were always corrected by the actual degree of dissociation of the radioactive molecules. The results suggest that [99mTc]-4-methylaminophenazone is suitable for the study of the circulatory changes in human gastric mucosa. It has the advantages of a much lower absorbed dose of radiation for the patient and his surroundings, a simplified measurement technique and considerably reduced expenses.