Martin P, Bateson P
Dev Psychobiol. 1982 Mar;15(2):139-57. doi: 10.1002/dev.420150207.
An experimental method for blocking maternal lactation is reviewed and the possible application of this technique for experimentally manipulating weaning is considered. Maternal milk production can be inhibited using the prolactin-suppressing drug bromocriptine. The suitability of bromocriptine for use in behavioural experiments is considered. The pharmacology of bromocriptine (CB 154) is briefly outlined and a compilation of the reported lactation-inhibiting doses for various species is presented. The possible endocrine and behavioral side-effects and the toxicity of the drug are discussed. It is concluded that, in most species studied so far, the drug is relatively free from significant side-effects at the low doses needed to suppress lactation. Guidelines for the practical use of bromocriptine are suggested. Finally, some ideas about the possible application of the drug to the study of behavioral development and parent-offspring relationships are discussed.
本文回顾了一种阻断母性行为中泌乳的实验方法，并探讨了该技术在实验性控制断奶方面的可能应用。使用抑制催乳素的药物溴隐亭可以抑制母鼠的乳汁分泌。本文考虑了溴隐亭在行为实验中的适用性。简要概述了溴隐亭（CB 154）的药理学，并列出了各种物种的报告泌乳抑制剂量。讨论了该药物可能的内分泌和行为副作用以及毒性。得出的结论是，在目前研究的大多数物种中，在抑制泌乳所需的低剂量下，该药物相对没有明显的副作用。建议了溴隐亭实际使用的指南。最后，讨论了关于该药物在行为发育和亲子关系研究中的可能应用的一些想法。
