Levine A S, Bond J H, Prentiss R A, Levitt M D
Gastroenterology. 1982 Sep;83(3):633-7.
The metabolism of carbon monoxide by the colonic flora was investigated using human fecal homogenates. During anaerobic incubation, these homogenates rapidly consumed added carbon monoxide reducing the PCO level to a minimum of about 0.2 ppm. In the presence of glucose, carbon monoxide consumption averaged about 0.7 ml/h . g feces and without glucose about 0.2 ml/h . g feces. This consumption was not observed if the homogenates were autoclaved, passed through a bacterial filter, or cultured aerobically, indicating that the carbon monoxide was removed by the metabolism of fecal anaerobes. Aerobic incubation of fecal homogenates resulted in slow but definite release of carbon monoxide. While bacterial carbon monoxide consumption probably does not play an appreciable role in the turnover of carbon monoxide that is inhaled or exogenously produced, it is possible that carbon monoxide uptake by colonic flora protects other fecal organisms and possibly the host from carbon monoxide liberated in the gut.
利用人类粪便匀浆研究结肠菌群对一氧化碳的代谢。在厌氧培养期间，这些匀浆迅速消耗添加的一氧化碳，将一氧化碳水平降至最低约0.2 ppm。在有葡萄糖存在的情况下，一氧化碳的消耗量平均约为0.7毫升/小时·克粪便，无葡萄糖时约为0.2毫升/小时·克粪便。如果匀浆经过高压灭菌、通过细菌过滤器或进行需氧培养，则未观察到这种消耗，这表明一氧化碳是通过粪便厌氧菌的代谢被去除的。粪便匀浆的需氧培养导致一氧化碳缓慢但确定的释放。虽然细菌对一氧化碳的消耗可能在吸入或外源性产生的一氧化碳的周转中不起重要作用，但结肠菌群对一氧化碳的摄取有可能保护其他粪便微生物以及宿主免受肠道中释放的一氧化碳的影响。
