Lowenfels A B, Domellöf L, Lindström C G, Bergman F, Monk M A, Sternby N H
Gastroenterology. 1982 Sep;83(3):672-6.
To study the relationship between gallstone disease (cholelithiasis and cholecystectomy) and cancer, a case-control study was performed in two Swedish hospitals comparing the prevalence of gallstone disease discovered at necropsy in 1422 subjects who died of cancer and 1205 subjects who did not die of cancer. Gallstone disease was more prevalent in the group of 131 women less than 50 yr of age who died of various cancers: odds ratio = 2.2, p less than 0.01. When the analysis was restricted to 89 younger women who died of cancers that have been suggested to be related to diet (breast, reproductive system, gastrointestinal), the results became more significant: odds ratio = 3.3, p less than 0.001. No such relationship was detected in older women or in men of any age. It seems likely that gallstone disease and several common cancers in younger Swedish women share similar epidemiologic and perhaps metabolic features.
为研究胆结石疾病（胆石症和胆囊切除术）与癌症之间的关系，在瑞典的两家医院开展了一项病例对照研究，比较了1422例死于癌症的受试者和1205例未死于癌症的受试者尸检时发现的胆结石疾病患病率。在131名年龄小于50岁、死于各种癌症的女性中，胆结石疾病更为普遍：优势比=2.2，p<0.01。当分析仅限于89名死于据认为与饮食有关的癌症（乳腺癌、生殖系统癌、胃肠道癌）的年轻女性时，结果变得更加显著：优势比=3.3，p<0.001。在老年女性或任何年龄的男性中未检测到这种关系。瑞典年轻女性中的胆结石疾病和几种常见癌症似乎具有相似的流行病学特征，也许还有代谢特征。
