• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

药物对颌下腺近端或远端交感神经切除术后肾上腺素能神经退变的延迟作用。

Delay by drugs of adrenergic nerve degeneration after proximal or distal sympathectomy of the submaxillary gland.

作者信息

Sanz N R, Stefano F J, Perec C J

出版信息

Gen Pharmacol. 1982;13(3):195-202. doi: 10.1016/0306-3623(82)90089-1.

DOI:10.1016/0306-3623(82)90089-1
PMID:7095398
Abstract
  1. Degeneration of nerve terminals of the submaxillary gland of the rat proceeds at a faster rate after crushing adrenergic nerves close to the gland than after ganglionectomy. 2. Bretylium, pargyline, nialamide and clorgyline delayed degeneration to the same extent after either type of denervation. 3. Chlorpromazine and pentobarbitone also delayed adrenergic degeneration, effect related to the hypothermia induced by these drugs. 4. Colchicine applied on the nerve trunk innervating the right gland delayed not only degeneration of the ipsilateral nerve terminals but the contralateral gland as well. 5. From the data obtained it seems probable that the drugs tested delay adrenergic nerve degeneration at the levels of nerve terminals. This effect is not related to lysosomal stabilization.
摘要
  1. 大鼠颌下腺神经末梢的退变，在紧靠腺体切断肾上腺素能神经后比在神经节切除术后进行得更快。2. 溴苄铵、帕吉林、尼亚酰胺和氯吉宁在任何一种去神经支配后，都能在相同程度上延缓退变。3. 氯丙嗪和戊巴比妥也能延缓肾上腺素能退变，其作用与这些药物诱导的体温过低有关。4. 应用于支配右侧腺体的神经干上的秋水仙碱，不仅延缓了同侧神经末梢的退变，也延缓了对侧腺体的退变。5. 从所获得的数据来看，所测试的药物似乎有可能在神经末梢水平延缓肾上腺素能神经退变。这种作用与溶酶体稳定无关。

相似文献

1
Delay by drugs of adrenergic nerve degeneration after proximal or distal sympathectomy of the submaxillary gland.药物对颌下腺近端或远端交感神经切除术后肾上腺素能神经退变的延迟作用。
Gen Pharmacol. 1982;13(3):195-202. doi: 10.1016/0306-3623(82)90089-1.
2
Delay by bretylium of adrenergic nerve degeneration after sympathectomy of the submaxillary gland.溴苄铵对颌下腺交感神经切除术后肾上腺素能神经变性的延迟作用。
Eur J Pharmacol. 1980 Jan 25;61(2):147-57. doi: 10.1016/0014-2999(80)90157-0.
3
Electron microscopic evidence that bretylium and pargyline delay adrenergic nerve degeneration after sympathectomy of the pineal gland.电子显微镜证据表明，溴苄铵和优降宁可延缓松果体交感神经切除术后肾上腺素能神经的变性。
Naunyn Schmiedebergs Arch Pharmacol. 1982 May;319(2):136-9. doi: 10.1007/BF00503926.
4
Time course of degeneration of short and long postganglionic sympathetic nerve fibres and effect of pentobarbitone and colchicine on degeneration.短和长节后交感神经纤维变性的时间进程以及戊巴比妥和秋水仙碱对变性的影响
Br J Pharmacol. 1978 Apr;62(4):553-61. doi: 10.1111/j.1476-5381.1978.tb07761.x.
5
Delay in nerve degeneration after sympathectomy of the submaxillary gland of the rat by treatment with pargyline, nialamide or beta-TM-10.用优降宁、尼亚酰胺或β-TM-10治疗大鼠颌下腺交感神经切除术后神经变性的延迟。
J Pharmacol Exp Ther. 1977 Sep;202(3):622-34.
6
Effects of drugs on the 6-hydroxydopamine induced degeneration of adrenergic nerves.药物对6-羟基多巴胺诱导的肾上腺素能神经变性的影响。
Res Commun Chem Pathol Pharmacol. 1972 May;3(3):543-56.
7
Changes in neuronal uptake and metabolism of, and sensitivity to, norepinephrine during the degeneration secretion in the rat submaxillary gland.大鼠颌下腺退变分泌过程中去甲肾上腺素的神经元摄取、代谢及敏感性变化。
J Pharmacol Exp Ther. 1974 Dec;191(3):403-17.
8
Effect of bretylium on degeneration secretion of saliva.溴苄铵对唾液变性分泌的影响。
Experientia. 1972 Aug 15;28(8):911. doi: 10.1007/BF01924940.
9
Degeneration mydriasis and hyperemia of the iris after superior cervical ganglionectomy in the rabbit. Evidence for release of more than norepinephrine during degeneration of adrenergic terminals.兔颈上神经节切除术后虹膜的变性、瞳孔散大及充血。肾上腺素能神经末梢变性过程中释放的物质不止去甲肾上腺素的证据。
Invest Ophthalmol. 1970 Nov;9(11):873-87.
10
Chronic sympathetic denervation increases muscarinic cholinoceptor binding in the rat submaxillary gland.慢性交感神经去神经支配增加大鼠颌下腺毒蕈碱型胆碱能受体结合。
Naunyn Schmiedebergs Arch Pharmacol. 1980 May;312(1):15-8. doi: 10.1007/BF00502567.

引用本文的文献

1
Ca2+ dependence of the release of noradrenaline during nerve degeneration in the parotid gland.腮腺神经退变过程中去甲肾上腺素释放的钙离子依赖性
Naunyn Schmiedebergs Arch Pharmacol. 1984 Nov;328(1):41-3. doi: 10.1007/BF00496104.