Davis S, Park Y K
Cancer Treat Rep. 1978 Oct;62(10):1557-9.
Fifty-four patients with clinical evidence of residual colorectal adenocarcinoma following surgical removal of the primary tumor were treated with a combination of 5-fluorouracil, mitomycin C, adriamycin, and cytosine arabinoside. The objective response rate in these patients was 17%. Bone marrow suppression was the major toxic effect. These data fail to show an advantage of this combination therapy over previously described chemotherapeutic regimens.
54例原发性肿瘤手术切除后有残留结直肠癌临床证据的患者接受了5-氟尿嘧啶、丝裂霉素C、阿霉素和阿糖胞苷联合治疗。这些患者的客观缓解率为17%。骨髓抑制是主要的毒性作用。这些数据未能显示出这种联合治疗相对于先前描述的化疗方案的优势。
