两例伴有神经原纤维缠结的皮克病尸检病例。
Two autopsy cases of Pick's disease with neurofibrillary tangles.
作者信息
Mitsunobu K, Ishino H
出版信息
Folia Psychiatr Neurol Jpn. 1982;36(1):89-98. doi: 10.1111/j.1440-1819.1982.tb00259.x.
Two cases of presenile dementia were presented. Both showed "stehende Redensarten" and aphasia. Histopathologically, besides Pick features--temporal lobe atrophy, fibrillary gliosis of the temporal white matter and neuronal loss in the 2--3 cortical layers--, Alzheimer features--neurofibrillary tangles and granulo-vacuolar degeneration--were found in both cases. But no senile plaques were found. Pseudocalcerous deposits were observed in the cerebral cortex, basal ganglia and cerebellum. Atypical cases with both Pick's and Alzheimer's diseases in the literature were classified into four groups according to the extent of the features of each disease. Sensory aphasia, which is relatively unusual in Pick's disease, was correlated to the atrophy of left T1, and similar cases in the literature were reviewed.
报告了两例早老性痴呆病例。两者均表现出“固定陈词滥调”和失语症。组织病理学上，除了皮克氏病特征——颞叶萎缩、颞叶白质的纤维性胶质增生以及2至3层皮质神经元丧失——之外，两例均发现了阿尔茨海默氏病特征——神经原纤维缠结和颗粒空泡变性。但未发现老年斑。在大脑皮质、基底神经节和小脑中观察到假钙化沉积。文献中同时患有皮克氏病和阿尔茨海默氏病的非典型病例根据每种疾病特征的程度分为四组。感觉性失语在皮克氏病中相对少见，与左侧颞叶1萎缩相关，并对文献中的类似病例进行了综述。
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