Batsakis J G, Regezi J A, Solomon A R, Rice D H
Head Neck Surg. 1982 May-Jun;4(5):404-18. doi: 10.1002/hed.2890040509.
Pigmented lesions, including melanomas, of the mucous membranes of the head and neck are far outnumbered by their counterparts in the skin. This relative dearth is partially responsible for the fact that scientific inquiry into mucosal melanomas has not kept pace with the advances in knowledge of the pathogenesis of cutaneous melanomas and their diagnosis and treatment. Integral to these latter advances have been the refinements in clinical and histologic classification and clinicopathologic correlations with quantitative evaluation of melanomas of skin-enhancements that up to now have been singularly lacking for mucosal melanomas. This report acknowledges this slowness in progress, present recommendations for purifying the nomenclature of pigmented lesions of the mucosae, and at the same time, also notes the poorer prognosis for melanomas of the upper aerodigestive tracts, as a group, when compared with cutaneous melanomas. Only prospective studies will answer the question of whether the poor prognosis is intrinsic to these mucosal melanomas or whether delay in detection and removal are responsible.
头颈部黏膜的色素沉着性病变，包括黑色素瘤，在数量上远远少于皮肤中的同类病变。这种相对较少的情况部分导致了对黏膜黑色素瘤的科学研究未能跟上皮肤黑色素瘤发病机制及其诊断和治疗知识的进展。这些后者进展的一个组成部分是临床和组织学分类的细化以及与皮肤黑色素瘤定量评估的临床病理相关性——这些改进至今在黏膜黑色素瘤中仍然非常缺乏。本报告承认进展缓慢，提出了净化黏膜色素沉着性病变命名法的建议，同时也指出，与皮肤黑色素瘤相比，上呼吸道消化道黑色素瘤作为一个整体，预后较差。只有前瞻性研究才能回答预后不良是这些黏膜黑色素瘤固有的，还是检测和切除延迟所致的问题。
