Teas D C, Klein A J, Kramer S J
Hear Res. 1982 May;7(1):19-54. doi: 10.1016/0378-5955(82)90080-6.
Acoustic brainstem responses (ABRs) were recorded from 148 infants from 4 to 60 weeks of age. 28 subjects returned to the laboratory 3 or more times for additional recordings. Filtered clicks of 1, 2, 4 and 8 kHz were presented at two intensities, 30 and 50 dB HL re the average threshold for a group of young adults. Responses to a broadband click, 50 dB nHL, were also recorded. The latencies of waves I, III and V were measured. Wave I latencies for the 8 kHz filtered click showed no change but those for lower frequencies decreased with age. The latency decreases with age were largest for wave V, and, among the filtered clicks, was largest for the responses to 1 kHz. Best-fitting curves were determined for latency vs. age for each filtered click and for the broadband click. Wave V--Wave I latency differences showed that the rostral conduction time for responses to the 8 kHz FC decreased with age and, for the 1 kHz filtered click (50 dB), remained constant. The early development of basal regions in the cochlea is viewed as insuring the delivery of a wide range of frequencies to rostral segments of the auditory system. The limiting feature of maturation is at rostral sites. The immature auditory system appears to be fully capable of transducing low frequency stimuli, but not high frequencies.
对148名4至60周龄的婴儿进行了听性脑干反应（ABR）记录。28名受试者返回实验室进行了3次或更多次的额外记录。以1、2、4和8千赫的滤波短声，在两种强度下呈现，即相对于一组年轻成年人的平均阈值为30和50分贝听力级（dB HL）。还记录了对50分贝正常听力级（dB nHL）的宽带短声的反应。测量了波I、波III和波V的潜伏期。8千赫滤波短声的波I潜伏期没有变化，但较低频率的波I潜伏期随年龄增长而缩短。波V潜伏期随年龄的缩短幅度最大，在滤波短声中，对1千赫反应的潜伏期缩短幅度最大。确定了每个滤波短声和宽带短声的潜伏期与年龄的最佳拟合曲线。波V与波I的潜伏期差异表明，对8千赫滤波短声反应的延髓传导时间随年龄增长而缩短，而对1千赫滤波短声（50分贝）的反应则保持不变。耳蜗基部区域的早期发育被认为可确保将广泛的频率传递至听觉系统的延髓部分。成熟的限制因素在于延髓部位。未成熟的听觉系统似乎完全能够传导低频刺激，但不能传导高频刺激。
