Lamesch A, Collin B
Chir Pediatr. 1978;19(2):131-3.
The purpose of this experimental work was to study the possibility of stress ulcer in fetal Surgery. Firstly an experimental model of production of stress ulcer by hypovolemic shock was worked out: by removing a volume of blood equivalent to 2% of body weight out of the femoral artery, a stress ulcer was was regularly induced in 25 female rabbits in the fundic area within 3 hours. In 10 pregnant rabbits and in the fetuses a stress ulcer could not be produced by the same method. This observation suggests the hypothesis that the reactions of the gastric wall are modified by the specific hormonal situation of the pregnant rabbit. This assumption ought to be elucidated by further investigations.
这项实验工作的目的是研究胎儿外科手术中发生应激性溃疡的可能性。首先,建立了一种通过低血容量性休克产生应激性溃疡的实验模型:从股动脉抽出相当于体重2%的血量,25只雌性兔子在3小时内胃底部区域均出现了应激性溃疡。而对于10只怀孕兔子及其胎儿,采用相同方法未能诱发应激性溃疡。这一观察结果提示了一种假说,即怀孕兔子的特定激素状态改变了胃壁的反应。这一假设有待进一步研究阐明。