Levison D A, Kingham J G, Dawson A M, Stansfeld A G
J Pathol. 1982 Jul;137(3):253-72. doi: 10.1002/path.1711370309.
We report the histological findings in livers from a group of 60 patients with benign intrahepatic portal hypertension. The lesion is benign in comparison with true cirrhosis in the sense that most of the patients survive many years from the time of diagnosis. The histological changes, in our view, differ from those of any variant of cirrhosis and generally do not progress even after many years. The essential features are: (1) irregular capsular thickening; (2) thickening of some portal tracts with fine fibrous septa radiating out from some of them; and (3) distortion of lobular architecture with hyperplastic expansion of some areas and compression of others and irregularly distributed central veins. We suggest that this is the lesion responsible for at least some cases of so-called idiopathic non-cirrhotic portal hypertension.
我们报告了一组60例良性肝内门静脉高压患者肝脏的组织学研究结果。与真正的肝硬化相比，该病变是良性的，因为大多数患者从诊断之时起能存活多年。我们认为，其组织学变化不同于任何肝硬化变体，即使多年后通常也不会进展。其基本特征为：（1）包膜不规则增厚；（2）一些门静脉分支增厚，并有纤细的纤维间隔从其中一些分支呈放射状延伸；（3）小叶结构扭曲，一些区域增生扩张，另一些区域受压，中央静脉分布不规则。我们认为，至少某些所谓的特发性非肝硬化性门静脉高压病例是由这一病变所致。
