Bell J E, Green R J
J Pathol. 1982 Aug;137(4):315-28. doi: 10.1002/path.1711370406.
The area cerebrovasculosa has been examined in 35 anencephalic fetuses and coronal sections prepared in 15 cases. A bilaterally symmetrical cystic mass is found covering the anterior and middle cranial fossae. The mass is generally walled with glial tissue, partially lined with ependyma and filled with abnormally vascular choroid plexus. The coverings of the cyst are conspicuously vascular and the overlying squamous epithelium is in continuity with hairy skin at the margins of the lesion. The posterior cranial fossa contains a variable quantity of medulla oblongata which has no connection with the cystic mass. The medulla and cervical cord are more nearly normal in that minority of cases with an intact foramen magnum. The degree of hindbrain development is correlated with previously reported presence of heterotopic glial tissue in the spinal subarachnoid space of some anencephalic fetuses (Bell, Gordon and Maloney, 1981; Bell, 1981, in press). These findings have led us to reject the widely accepted view that the area cerebrovasculosa is totally disorganised, and that anencealy is characterised by absence of the forebrain.
对35例无脑儿胎儿的脑血管区进行了检查，并对其中15例制作了冠状切片。发现一个双侧对称的囊性肿物覆盖前颅窝和中颅窝。该肿物通常由神经胶质组织包被，部分内衬室管膜，充满异常血管的脉络丛。囊肿的被膜血管明显，其上方的鳞状上皮与病变边缘的多毛皮肤相连。后颅窝含有数量不等的延髓，与囊性肿物无连接。在少数枕骨大孔完整的病例中，延髓和颈髓更接近正常。后脑发育程度与先前报道的一些无脑儿胎儿脊髓蛛网膜下腔中异位神经胶质组织的存在相关（贝尔、戈登和马洛尼，1981年；贝尔，1981年，即将发表）。这些发现使我们摒弃了广泛接受的观点，即脑血管区完全紊乱，无脑畸形的特征是前脑缺失。
