Savage T S, Wells C E
J Pharm Sci. 1982 Jun;71(6):670-3. doi: 10.1002/jps.2600710616.
The effect of sampling probe size and location on the in vitro dissolution rate of prednisone tablets was examined. Using USP XX Apparatus 2 with an automated sampling system, dissolution rates were determined using two types of large filter-tipped probes and a small capillary probe. Each probe was tested at three locations within the kettle. The large probes caused hydrodynamic changes which, when compared with results obtained through manual sampling, resulted in significant changes in dissolution rates at each location. These changes were less evident when the capillary probe was used, with an insignificant difference between results of automated and manual sampling when the capillary probe was placed midway between the paddle shaft and the kettle wall.
研究了取样探头尺寸和位置对泼尼松片体外溶出速率的影响。使用配备自动取样系统的美国药典XX装置2，采用两种大型带滤头探头和一种小型毛细管探头测定溶出速率。每个探头在溶出杯内的三个位置进行测试。大型探头引起了流体动力学变化，与手动取样得到的结果相比，每个位置的溶出速率都发生了显著变化。使用毛细管探头时，这些变化不太明显，当毛细管探头放置在搅拌轴和溶出杯壁中间位置时，自动取样和手动取样的结果差异不显著。
