蒽醌类化合物的构效关系研究：1,4 - 二羟基 - 5,8 - 双[[2 - (2 - 羟基乙氧基)乙基]氨基] - 9,10 - 蒽二酮，一种已确立的抗肿瘤药物的类似物。
Structure-activity relationship study of anthraquinones: 1,4-dihydroxy-5,8-bis[[2-(2-hydroxyethoxy)ethyl]amino]-9,10-anthracenedione, an analog of an established antineoplastic agent.
作者信息
Zee-Cheng R K, Cheng C C
出版信息
J Pharm Sci. 1982 Jun;71(6):708-9. doi: 10.1002/jps.2600710626.
PMID:7097541
Abstract
An oxygen analog of the antineoplastic anthraquinone, 1,4-dihydroxy-5,8-bis[[2-(2-hydroxyethyl)amino]ethyl]amino - 9,10-anthracenedione, was synthesized. This compound, 1,4-dihydroxy-5,8-bis[[2-(2-hydroxyethoxy)ethyl]amino] - 9,10-anthracenedione, was found to be inactive against P-388 lymphocytic leukemia. A comparative structure-activity study of these two anthraquinones in terms of previously postulated N--O--O triangulation hypothesis was discussed.
摘要
合成了抗肿瘤蒽醌的氧类似物，即1,4 - 二羟基 - 5,8 - 双[[2 - (2 - 羟乙基)氨基]乙基]氨基 - 9,10 - 蒽二酮。发现该化合物1,4 - 二羟基 - 5,8 - 双[[2 - (2 - 羟乙氧基)乙基]氨基] - 9,10 - 蒽二酮对P - 388淋巴细胞白血病无活性。根据先前提出的N - O - O三角剖分假说，对这两种蒽醌进行了比较结构 - 活性研究。
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