Shea-Donohue P T, Nompleggi D, Myers L, Dubois A
J Pharmacol Exp Ther. 1982 Aug;222(2):379-82.
The effects of a stable endoperoxide analog, U-46619, were studied in five conscious chair-adapted rhesus monkeys. A dye dilution technique was used to determine simultaneously gastric fractional emptying, fluid output and ion output. A continuous infusion of either saline or U-46619 (0.2 micrograms/kg/min i.v.; 1 or 2 micrograms/kg/min s.c.) was given during a basal period and after distension of the stomach with an 80-ml water load. These studies demonstrate that U-46619 increases basal, but not postload fractinal emptying, and inhibits parietal secretion. These actions are similar to some of the effects of prostacyclin, prostaglandin E2 and prostaglandin F2 alpha on gastric emptying and secretion.
在五只适应座椅的清醒恒河猴身上研究了一种稳定的内过氧化物类似物U - 46619的作用。采用染料稀释技术同时测定胃排空分数、液体排出量和离子排出量。在基础期以及用80毫升水负荷使胃扩张后，持续输注生理盐水或U - 46619（静脉注射0.2微克/千克/分钟；皮下注射1或2微克/千克/分钟）。这些研究表明，U - 46619增加基础胃排空分数，但不增加负荷后胃排空分数，并抑制壁细胞分泌。这些作用类似于前列环素、前列腺素E2和前列腺素F2α对胃排空和分泌的一些影响。
