Sachs B L, Goldberg V M, Getzy L L, Moskowitz R W, Malemud C J
J Rheumatol. 1982 Mar-Apr;9(2):210-6.
A histopathologic system of classifying minced human hip and knee osteoarthritic cartilage often used in organ cultures was developed. The tissue types characterizing the cartilage fragments were correlated with characteristics noted in full thickness cartilage specimens from young normal, aged and osteoarthritic cartilage. In the minced tissue specimens 3 distinct tissue types (A, B, and C) were discerned. Tissue types A and B were seen in nonfibrillated discolored as well as fibrillated osteoarthritic cartilage. Type C tissue was derived principally from chondroosteophytic spurs. Each tissue type differed in the number and organization of chondrocytes and orthochromatic and metachromatic staining of the perilacunar region and interterritorial matrix. No A, B or C tissue types were seen in normal cartilage samples derived from patients below the age of 50. Cartilage from patients above this age contained elements of all 3 tissue types.
开发了一种常用于器官培养的对人髋和膝骨关节炎软骨碎片进行组织病理学分类的系统。表征软骨碎片的组织类型与来自年轻正常、老年和骨关节炎软骨的全层软骨标本中观察到的特征相关。在切碎的组织标本中，可识别出3种不同的组织类型（A、B和C）。组织类型A和B可见于未纤维化变色以及纤维化的骨关节炎软骨中。C型组织主要来源于软骨骨赘。每种组织类型在软骨细胞的数量和组织以及陷窝周围区域和领地间基质的正色和异染性染色方面都有所不同。在50岁以下患者的正常软骨样本中未见到A、B或C型组织。该年龄以上患者的软骨包含所有3种组织类型的成分。
